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KMID : 0043320010240010021
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Archives of Pharmacal Research
2001 Volume.24 No. 1 p.21 ~ p.26
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Synthesis and Antihypertensive Activity of Certain Mannich Bases of 2-Ethoxycarbonylindoles and 5H-pyridazino[4,5-b]indoles
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El-Gendy AA
El-Banna HA
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Abstract
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This manuscript reports the synthesis of two series of Mannich Bases 3-12 and 21-40 obtained respectively by the reaction of either 2-ethoxycarbonylindoles 1-2 or 5H- pyridazino [4,5-b]inoles 17-20 as a substrate with formalin and the appropriate 2o amines under the suitable Mannich conditions. Fourteen of the synthesized Mannich basese were screened as antihypetensive agents in normotensive anesthetized rats. The effect of compound 4 in normotensive anesthetized dogs was also studied.
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KEYWORD
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